Motivation: Semantic tagging of organism mentions in full-text articles is an important part of literature mining and semantic enrichment solutions. Tagged organism mentions also play a pivotal role in disambiguating other entities in a text, such as proteins. A high-precision organism tagging system must be able to detect the numerous forms of organism mentions, including common names as well as the traditional taxonomic groups: genus, species and strains. In addition, such a system must resolve abbreviations and acronyms, assign the scientific name and if possible link the detected mention to the NCBI Taxonomy database for further semantic queries and literature navigation.
Results: We present the OrganismTagger, a hybrid rule-based/machine learning system to extract organism mentions from the literature. It includes tools for automatically generating lexical and ontological resources from a copy of the NCBI Taxonomy database, thereby facilitating system updates by end users. Its novel ontology-based resources can also be reused in other semantic mining and linked data tasks. Each detected organism mention is normalized to a canonical name through the resolution of acronyms and abbreviations and subsequently grounded with an NCBI Taxonomy database ID. In particular, our system combines a novel machine-learning approach with rule-based and lexical methods for detecting strain mentions in documents. On our manually annotated OT corpus, the OrganismTagger achieves a precision of 95%, a recall of 94% and a grounding accuracy of 97.5%. On the manually annotated corpus of Linnaeus-100, the results show a precision of 99%, recall of 97% and grounding accuracy of 97.4%.
Availability: The OrganismTagger, including supporting tools, resources, training data and manual annotations, as well as end user and developer documentation, is freely available under an open-source license at http://www.semanticsoftware.info/organism-tagger.
Mutation impact extraction is a hitherto unaccomplished task in state of the art mutation extraction systems. Protein mutations and their impacts on protein properties are hidden in scientific literature, making them poorly accessible for protein engineers and inaccessible for phenotype-prediction systems that currently depend on manually curated genomic variation databases.
We present the first rule-based approach for the extraction of mutation impacts on protein properties, categorizing their directionality as positive, negative or neutral. Furthermore protein and mutation mentions are grounded to their respective UniProtKB IDs and selected protein properties, namely protein functions to concepts found in the Gene Ontology. The extracted entities are populated to an OWL-DL Mutation Impact ontology facilitating complex querying for mutation impacts using SPARQL. We illustrate retrieval of proteins and mutant sequences for a given direction of impact on specific protein properties. Moreover we provide programmatic access to the data through semantic web services using the SADI (Semantic Automated Discovery and Integration) framework.
We address the problem of access to legacy mutation data in unstructured form through the creation of novel mutation impact extraction methods which are evaluated on a corpus of full-text articles on haloalkane dehalogenases, tagged by domain experts. Our approaches show state of the art levels of precision and recall for Mutation Grounding and respectable level of precision but lower recall for the task of Mutant-Impact relation extraction. The system is deployed using text mining and semantic web technologies with the goal of publishing to a broad spectrum of consumers.
NLP methods for extracting mutation information from the bibliome have become an important new research area within bio-NLP, as manually curated databases, like the Protein Mutant Database (PMD) (Kawabata et al., 1999), cannot keep up with the rapid pace of mutation research. However, while significant progress has been made with respect to mutation detection, the automated extraction of the impacts of these mutations has so far not been targeted. In this paper, we describe the first work to automatically summarize impact information from protein mutations. Our approach is based on populating an OWL-DL ontology with impact information, which can then be queried to provide structured information, including a summary.
Nowadays, software development and maintenance are highly distributed processes that involve a multitude of supporting tools and resources. Knowledge relevant for a particular software maintenance task is typically dispersed over a wide range of artifacts in different representational formats and at different abstraction levels, resulting in isolated 'information silos'. An increasing number of task-specific software tools aim to support developers, but this often results in additional challenges, as not every project member can be familiar with every tool and its applicability for a given problem. Furthermore, historical knowledge about successfully performed modifications is lost, since only the result is recorded in versioning systems, but not how a developer arrived at the solution. In this research, we introduce conceptual models for the software domain that go beyond existing program and tool models, by including maintenance processes and their constituents. The models are supported by a pro-active, ambient, knowledge-based environment that integrates users, tasks, tools, and resources, as well as processes and history-specific information. Given this ambient environment, we demonstrate how maintainers can be supported with contextual guidance during typical maintenance tasks through the use of ontology queries and reasoning services.
Providing access to cultural heritage data beyond book digitization and information retrieval projects is important for delivering advanced semantic support to end users, in order to address their specific needs. We introduce a separation of concerns for heritage data management by explicitly defining different user groups and analyzing their particular requirements. Based on this analysis, we developed a comprehensive system architecture for accessing, annotating, and querying textual historic data. Novel features are the deployment of a Wiki user interface, natural language processing services for end users, metadata generation in OWL ontology format, SPARQL queries on textual data, and the integration of external clients through Web Services. We illustrate these ideas with the management of a historic encyclopedia of architecture.
In this paper, we present a formal process model to support the comprehension and maintenance of software systems. The model provides a formal ontological representation that supports the use of reasoning services across different knowledge resources. In the presented approach, we employ our Description Logic knowledge base to support the maintenance process management, as well as detailed analyses among resources, e.g., the traceability between various software artifacts. The resulting unified process model provides users with active guidance in selecting and utilizing these resources that are context-sensitive to a particular comprehension task. We illustrate both, the technical foundation based on our existing SOUND environment, as well as the general objectives and goals of our process model.
Keywords: Software maintenance, process modeling, ontological reasoning, software comprehension, traceability, text mining.
Traceability links provide support for software engineers in understanding the relations and dependencies among software artifacts created during the software development process. In this research, we focus on re-establishing traceability links between existing source code and documentation to support reverse engineering. We present a novel approach that addresses this issue by creating formal ontological representations for both the documentation and source code artifacts.
Do you have a lack of information? Or do you rather feel overwhelmed by the sheer amount of (online) available content, like emails, news, web pages, and electronic documents? The rather young field of Text Mining developed from the observation that most knowledge today - more than 80% of the data stored in databases - is hidden within documents written in natural languages and thus cannot be automatically processed by traditional information systems.
Text Mining, "also known as intelligent text analysis, text data mining or knowledge-discovery in text (KDT), refers generally to the process of extracting interesting and non-trivial information and knowledge from unstructured text." Text Mining is a highly interdisciplinary field, drawing on foundations and technologies from fields like computational linguistics, database systems, and artificial intelligence, but applying these in new and often unconventional ways.